An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

Ivona Aksentijevich; Seth L. Masters; Polly J. Ferguson; Paul Dancey; Joost Frenkel; Annet van Royen-Kerkhoff; Ron Laxer; Ulf Tedgård; Edward W. Cowen; Tuyet-Hang Pham; Matthew Booty; Jacob D. Estes; Netanya G. Sandler; Nicole Plass; Deborah L. Stone; Maria L. Turner; Suvimol Hill; John A. Butman; Rayfel Schneider; Paul Babyn; Hatem I. El-Shanti; Elena Pope; Karyl Barron; Xinyu Bing; Arian Laurence; Chyi-Chia R. Lee; Dawn Chapelle; Gillian I. Clarke; Kamal Ohson; Marc Nicholson; Massimo Gadina; Barbara Yang; Benjamin D. Korman; Peter K. Gregersen; P. Martin van Hagen; A. Elisabeth Hak; Marjan Huizing; Proton Rahman; Daniel C. Douek; Elaine F. Remmers; Daniel L. Kastner; Raphaela Goldbach-Mansky

Journal ArticleOPEN ACCESS

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

Aksentijevich I
Masters S
Ferguson P
et al.

New England Journal of Medicine (2009) 360(23) 2426-2437

DOI: 10.1056/nejmoa0807865

889Citations

351Readers

Abstract

Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone.

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APA

Aksentijevich, I., Masters, S. L., Ferguson, P. J., Dancey, P., Frenkel, J., van Royen-Kerkhoff, A., … Goldbach-Mansky, R. (2009). An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist. New England Journal of Medicine, 360(23), 2426–2437. https://doi.org/10.1056/nejmoa0807865

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

Abstract

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