A longitudinal study of PSA and its influential factors in a cohort of Chinese men with initial PSA levels less than 4 ng ml -1

Abstract

To evaluat. The longitudinal change in prostate-specific antigen (PSA) an. The influence of initial PSA o. The PSA change. We retrospectively analysed health examination data collected at Beijing Hospital from March 2007 to November 2011. Men with an initial PSA levels less than 4 ng ml -1 and an annual PSA test for 5 years were enrolled int. The study. The men were separated into four groups b. The initial PSA level (0-0.99, 1-1.99, 2-2.99 and 3-3.99 ng ml -1), an. The difference in PSA change amon. The four groups was analysed. A total of 1330 men were enrolled int. The study. The mean age, initial PSA and PSA velocity (PSAV) were 58.17±14.63 (range 24-91) years, 1.18±0.79 (range 0-4) ng ml -1 and 0.04±0.25 (range -1.34-2.02) ng ml -1 year -1. Pearson's correlation analysis showed no correlation between initial PSA and PSAV (r=-0.036, P=0.189). The PSAV o. The 0-0.99, 1-1.99, 2-2.99 and 3-3.99 ng ml -1 initial PSA groups was 0.03±0.11, 0.07±0.32, 0.03±0.34 and -0.01±0.43 ng ml -1 year -1, respectively (P=0.06). A. The initial PSA increased. The percentage of having a PSAV over 0.75 ng ml -1 year -1 and a negative PSAV both significantly increased. Males with a baseline PSA of 0-0.99, 1-1.99, 2-2.99 and 3-3.99 ng ml -1 had a 1.88%, 6.16%, 16.30% and 57.81% chance, respectively, that their PSA would increase above 4.0 ng ml -1 ove. The following 4 years (P<0.0001). The PSAV has no correlation wit. The initial PSA level. However, a. The initial PSA increases. The chance that males will have an abnormal PSA or PSAV i. The future increases.