Study of the synthesis of novel trisubstituted acridines

Abstract

An efficient methodology has been developed for the synthesis of 3,6-diamino-9-[(phenylalkyl)amino]acridines by heating 2-propanol solutions of 3,6-di(butanoylamino)-9-[(phenylalkyl)amino]acridines in the presence of NaOH. 3,6-Diamino-9-[(phenylalkyl)amino]acridines were used in the synthesis of final products 3,6-bis{3-[2-(dimethylamino)ethyl]ureido}-9-[(phenylalkyl)amino]acridines. Herein we rationalize the formation of 3,6,9-triaminoacridine and propose the reaction mechanism for the observed transformation.