Abstract
Serum-stabilized PNA-internalization peptides (Pip) conjugated to PNA complementary to the 705 aberrant beta-globin splice site are able to correct splicing and increase luciferase production in Hela pLuc705 cells with sub microM EC(50) in the absence of a transfection agent. Inhibition of microRNA-122 in liver cells is achieved by treatment with complementary PNA containing just a few attached Lys residues, again without need of a transfection agent.
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CITATION STYLE
Ivanova, G. D., Fabani, M. M., Arzumanov, A. A., Abes, R., Yin, H., Lebleu, B., … Gait, M. J. (2008). PNA-peptide conjugates as intracellular gene control agents. Nucleic Acids Symposium Series (2004), (52), 31–32. https://doi.org/10.1093/nass/nrn016
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