PO-0830 Is There Any Correlation Between Polymorphism C677t Methylenetetrahydropholate Reductase (mthfr) Gene And Homocysteine Level In Cerebral Palsy?

Abstract

Background Cerebral palsy (CP) is common cause of disability in children. The aetiology of cerebral injury in CP is multifactorial, and recent studies suggested that genetic factor maybe contributed to the development of CP. Polymorphism C677T MTHFR gene influenced homocysteine metabolism that has neurotoxic effect. Aim This is a preliminary study. The aim of this study was to evaluate the correlation between polymorphism C677T MTHFR gene and homocysteine level in CP children in Bandung, Indonesia. Methods This is the cross sectional study. The CP children, 4-14 years old were analysed C677T polymorphism in the MTHFR gene and homocysteine level. The data of this study were analysed with SPSS program, t-tests were used, and statistical significance was defined as p value