Synthesis, Structural Studies and Antimicrobial Evaluation of Nickel(II) Bis-Complex of Schiff Base of S-Benzyldithiocarbazate

Abstract

A tridentate nitrogen-oxygen-sulfur (NOS) S-benzyl(2-oxoindolin-3-ylidene)dithiocarbazate, HSBISA (HL1) ligand was synthesized via a condensation reaction between S-benzylditihocarbazate (SBDTC) and isatin. The produced ligand was reacted with nickel(II) acetate salt in 1:2 (metal:ligand) ratio to yield a brown Ni(SBISA)2 complex (2) (SBISA = monoanionic form of HL1). Characterization of HL1 and its Ni(II) complex was performed via elemental analysis, FT-IR, ICP-AES, UV-Vis spectroscopy and mass spectrometry, along with molar conductivity and magnetic susceptibility measurement. Slow evaporation of 2 from DMSO at room temperature led to a structure crystallizing in the monoclinic P21 = 112.1897(10), V = 3891.86(11) Åb/a space group with a = 18.6860(3), b = 11.3037(2), c = 19.8993(3),3, wR2 (all data) = 0.0407 and R1 = 0.0386 for data with I > 2σ(I). The nickel(II) metal center is ligated by doubly-deprotonated NOS monoanionic tridentate HL1 ligands forming a neural distorted octahedral Ni(SBISA)22DMSO (2a) complex. The antimicrobial assays of both compounds were performed on selected pathogenic bacteria and fungi strains.×.