Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery

Abstract

Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association.