Abstract
The interaction of human immunodeficiency virus (HIV)-derived vectors with wild-type virus was analyzed in transduced cells. Vector transcripts upregulated by infection had no measurable effect on HIV type 1 (HIV-1) expression but competed efficiently for encapsidation, inhibiting the infectivity and spread of HIV-1 in culture and leading to mobilization and recombination of the vector. These effects were abrogated with a self-inactivating vector.
Cite
CITATION STYLE
Bukovsky, A. A., Song, J.-P., & Naldini, L. (1999). Interaction of Human Immunodeficiency Virus-Derived Vectors with Wild-Type Virus in Transduced Cells. Journal of Virology, 73(8), 7087–7092. https://doi.org/10.1128/jvi.73.8.7087-7092.1999
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