Formulation and Evaluation of Solid Dispersion Chitosan Tablet from Whiteleg Shrimp (Litopenaeus vannamei) Using PVP K-30 As a Carriers

Abstract

Whiteleg shrimp (Litopenaeus vannamei) on the market are processed or sold only to take part in the meat. The head, shell, and tail are thrown away without any prior processing. Underutilized waste causes environmental problems. An alternative to overcome this environmental disturbance phenomenon is to utilize shrimp shells containing chitin and subsequently transformed into chitosan that can be applied in various fields. Chitosan has poor solubility in water but high permeability, so to improve bioavailability is by making solid dispersions. Chitosan solid dispersion made by the solvent evaporation technique used PVP K-30 as the carriers. The result of chitosan solid dispersion was then molded into tablets by the direct compression method. Hence the tablets were evaluated by weight and size uniformity, hardness, friability, and disintegration time. The formulation divided into three groups, that is F1 (chitosan : PVP K-30 = 1 : 1 solid dispersion), F2 (chitosan : PVP K-30 = 1 : 3 solid dispersion), and F3 (pure chitosan). All the formulas by weight and size uniformity and disintegration time fulfill the requirements. F3 hardness is 4,275 kg is the best from F1 and F2. By statistic analytical from weight uniformity, hardness and disintegration time give significant difference with sig. <0,05.