XRCC4 c.1394G > T single nucleotide polymorphisms and breast cancer risk among filipinos

Abstract

Background: The identification of cancer-associated single nucleotide polymorphisms (SNP) and mutation genes is a promising approach in recognizing individuals who are at risk of developing cancer. Hence, this study was conducted to determine the association between XRCC4 c.1394G > T SNP and breast cancer development among Filipinos. Methods: Genotyping for XRCC4 c.1394G > T SNP was performed on breast cancer patients (n=103) and their age- and sex- matched clinically healthy controls (n=103) by polymerase chain reaction - restriction fragment length polymorphism. Results: Significant difference in genotype (p=0.007) and allele (p=0.003) frequencies in XRCC4 c.1394G > T was observed between the breast cancer cases and controls. Carriers of the XRCC4 c.1394 G > T genotype were observed to have significantly higher risk of developing breast cancer compared to individuals with T/T genotype (OR=2.67, 95% CI: 1.36 - 5.25). XRCC4 c.1394G > T combined with passive smoking may also significantly increase risk of breast cancer (OR=14.73; 95% CI= 9.88-18.86). Conclusion: XRCC4 c. 1394G > T may be associated with breast cancer development among Filipinos.