Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

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Abstract

α-anomeric uridylates, α-rU6 and α-rU12, have been synthesized for the first time. These non natural α-oligoribonucleotides strongly resist to enzymatic degradation and bind to complementary RNA strands. © 1990.

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Debart, F., Rayner, B., & Imbach, J. L. (1990). Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents. Tetrahedron Letters, 31(25), 3537–3540. https://doi.org/10.1016/S0040-4039(00)94436-8

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