One-step fabrication of biocompatible chitosan-coated ZnS and ZnS:Mn 2+ quantum dots via a γ- radiation route

Abstract

Biocompatible chitosan-coated ZnS quantum dots [CS-ZnS QDs] and chitosan-coated ZnS:Mn 2+ quantum dots [CS- ZnS:Mn 2+ QDs] were successfully fabricated via a convenient one-step g-radiation route. The as-obtained QDs were around 5 nm in diameter with excellent water-solubility. These QDs emitting strong visible blue or orange light under UV excitation were successfully used as labels for PANC-1 cells. The cell experiments revealed that CS-ZnS and CS-ZnS:Mn 2+ QDs showed low cytotoxicity and good biocompatibility, which offered possibilities for further biomedical applications. Moreover, this convenient synthesis strategy could be extended to fabricate other nanoparticles coated with chitosan. PACS: 81.07.Ta; 78.67.Hc; 82.35.Np; 87.85.Rs. © 2011 Chang et al.