HOX s and lincRNAs: Two sides of the same coin

Abstract

The Hox complexes: Domains of dynamic interplay between coding and noncoding transcripts. The clustered Hox genes play fundamental roles in regulation of axial patterning and elaboration of the basic body plan in animal development. There are common features in the organization and regulatory landscape of Hox clusters associated with their highly conserved functional roles. The presence of transcribed noncoding sequences embedded within the vertebrate Hox clusters is providing insight into a new layer of regulatory information associated with Hox genes.