Synthesis of bioactive sialosides

Abstract

Sialosides of glycoprotein and glycolipid carbohydrate groups are well documented to play important roles in biological recognition. This class of oligosaccharides also poses unique challenges to the synthetic chemist. Accordingly, the synthesis of natural sialosides and related analogs has been the subject of intense investigations over the last decade. Advances in both chemical and enzymatic approaches to the synthesis of sialosides have lead to increasingly practical synthetic strategies. Recent progress is summarized in this report with emphasis on the strategies for the use of sialyltransferases in enzymatic sialylation. © 1993 IUPAC