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Catalyst-free tandem Knoevenagel-Michael reaction of aldehydes and pyrazolin-5-one: Fast and convenient approach to medicinally relevant 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol)s

Heterocyclic Communications (2015) 21(2) 97-101
DOI: 10.1515/hc-2015-0046
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Abstract

Catalyst-free tandem Knoevenagel-Michael reaction of aryl aldehydes and two equivalents of 3-methyl-1-phenyl-2-pyrazolin-5-one results in fast (5 min) formation of medicinally relevant 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol)s in excellent 93%-99% yield.

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Elinson, M. N., Sokolova, O. O., & Nasybullin, R. F. (2015). Catalyst-free tandem Knoevenagel-Michael reaction of aldehydes and pyrazolin-5-one: Fast and convenient approach to medicinally relevant 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol)s. Heterocyclic Communications, 21(2), 97–101. https://doi.org/10.1515/hc-2015-0046

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