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Circulating Cell-Free Mitochondrial DNA in Pregnancy

Physiology (2022) 37(4) 187-196
DOI: 10.1152/physiol.00037.2021
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Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.

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Bradshaw, J. L., Cushen, S. C., Phillips, N. R., & Goulopoulou, S. (2022). Circulating Cell-Free Mitochondrial DNA in Pregnancy. Physiology, 37(4), 187–196. https://doi.org/10.1152/physiol.00037.2021

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