Retrograde flow of cadherins in collective cell migration

Abstract

Collective cell migration is characterized by the maintenance of intercellular contacts during cell movement. The maintenance of N-cadherin-based junctions during collective migration is now shown to be facilitated by their treadmilling from the cell front to the rear, followed by N-cadherin endocytosis and recycling to the leading edge. © 2014 Macmillan Publishers Limited. All rights reserved.