Soluble urokinase-type plasminogen activator receptor strongly predicts global mortality in acute heart failure patients: Insight from the STADE-HF registry

Abstract

Background: Whether soluble urokinase-type plasminogen activator receptor (suPAR) could be a valuable prognostic indicator remains uncertain. Materials and methods: Patients from STADE-HF (Soluble Suppression of Tumorigenesis-2 as a Help for Management of Diagnosis, Evaluation and Management of Heart Failure) were included for analysis. Results: 95 patients were included. The suPAR level of expression was significantly higher in the group of patients who died at one month (7.90 ± 4.35 ng/ml vs 11.94 + 6.86 ng/ml; p < 0.05) or 1 year (7.28 ± 4.27 ng/ml vs 11.81 + 4.88 ng/ml; p < 0.01), but there was no significant difference according to the readmission. Conclusion: High suPAR levels during hospitalization for acute heart failure were highly predictive for the risk of mortality, but not the risk of readmission. Finding the best biomarker to evaluate prognosis in heart failure is challenging. Our objective is to evaluate the soluble urokinase-type plasminogen activator receptor prognosis performance in acute heart failure (AHF) patients on global mortality, risk of readmission after an acute heart failure, using the STADE-HF cohort of patients. The soluble urokinase-type plasminogen activator receptor level of expression was significantly higher in the group of patients who died during follow-up, but there was no significant difference according to the readmission for heart failure. This could help to stratify patients.