Improved Protein Phosphorylation Site Prediction by a New Combination of Feature Set and Feature Selection

Abstract

Phosphorylation of protein is an important post-translational modification that enables activation of various enzymes and receptors included in signaling pathways. To reduce the cost of identifying phosphorylation site by laborious experiments, computational prediction of it has been actively studied. In this study, by adopting a new set of features and applying feature selection by Random Forest with grid search before training by Support Vector Machine, our method achieved better or comparable performance of phosphorylation site prediction for two different data sets.