Endophytic fungi from tropical ethnoveterinary plants and their antibacterial efficacy against Pasteurella multocida Capsular Type A strain

Abstract

Four endophytic fungi out of six, isolated from two tropical ethnoveterinary plants- Garcinia xanthochymus H. and Polygonum chinense L. showed antimicrobial activity against Pasteurella multocida Capsular Type A strains. The best antibacterial activity was showed by the extract of endophytic fungi Glomerella magna isolated from Garcinia xanthochymus with a minimum inhibitory concentration of 46.9 µg/ml and minimum bactericidal concentration of 750 µg/ml. Treatment of mice with the potent fungal extract caused a considerable inhibitory effect on the growth of the pathogen in vital organs of mice. Histopathological studies of animal organs by scanning electron microscopy also confirmed these findings. These present findings indicate that the endophytic fungi Glomerella magna has potential to provide an effective treatment to Pasteurella multocida infections.