Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza

Abstract

The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives. dan-shen; Salvia miltiorrhiza; adenylate cyclase; rosemarinic acid; lithospermic acid,. © 1989, The Pharmaceutical Society of Japan. All rights reserved.