Study of Antidiabetic Activity of Aqueous Extract of Clerodendrum colebrookianum Leaves

Abstract

Clerodendrum colebrookianum is commonly distributed in North eastern reagion of India. Clerodendrum colebrookianum leaves are reported to be used in the herbal antidiabetic medicines. The aim of this study was to investigate the antidiabetic property of Clerodendrum colebrookianum leaves in diabetic mice. Diabetes mellitus was induced in experimental mice by intraperitoneal administration of alloxan monohydrate. Diabetic mice showed increase in blood glucose levels after 72 hrs of alloxan administration. Effects of aqueous extracts of Clerodendrum colebrookianum leaves on normal and alloxan-induced diabetic mice were investigated in four groups of mice (six mice per group). The levels of blood glucose of mice were examined in all four experimental groups. Phytochemical screening of the leaf extracts of Clerodendrum colebrookianum indicated the presence of carbohydrates, flavonoids, tannins, phenolic compounds, glycosides, and terpenoids. The mice were administered orally with the aqueous extracts of Clerodendrum colebrookianum leaves with a single dose of 400 mg/kg body weight per day. The leaf of Clerodendrum colebrookianum was found to have blood sugar lowering potential in alloxan induced diabetic mice. The present study has established the anti-diabetic effect of Clerodendrum colebrookianum leaves.