Antibacterial activity of bsa-capped gold nanoclusters against methicillin-resistant staphylococcus aureus (mrsa) and vancomycin-intermediate Staphylococcus aureus (VISA)

Abstract

The emergence of drug-resistant pathogens and the abuse of antibiotics have posed dominant threats to society. In this study, we propose an antibacterial use of bovine serum albumin-capped gold nanoclusters (BSA-AuNCs) to address the issue. BSA-AuNCs have a great antibacterial activity against MRSA and VISA which is proved by time-killing curves (TKC). The possible antibacterial mechanisms of BSA-AuNCs against MRSA and VISA are confirmed by fluorescence image observation.