[NF-kB activation as a molecular basis of pathological process by metabolic syndrome].

Abstract

The paper examines the formation of evolutionary advanced causal factors set in modern conditions which may cause new pathological condition (state), being implemented through evolutionary fixed and standard pathological processes. The analysis of the notion of "metabolic syndrome" and its components has been performed. The correlation between insulin resistance, chronic inflammation, arterial hypertension, endothelial dysfunction and dyslipidemia has been indicated as the manifestations of one pathologic process, the central molecular basis of which is the activation of NF-kB. At the current stage it has been suggested to set up the conception of NF-kB permanent (long-lasting, low grade) activation as a possible model of pathological process.