Synthesis And Antifungal Properties of Some N, Y'-bis-azolylarylmethanes

Abstract

A series of l,l'-bis-azolylarylmethanes has been prepared by reaction of azoles and their benzoderivatives with ortho-, and para-chlorobenzaldehydes thiophene-2-carbaldehyde and furan-2-carbaldehyde in the presence of zinc chloride as catalyst. The antifungal activity has been tested, in vitro, against Botrytis cinerea, Aspergillus flaws, Mucor rouxii and Candida albicans. All 1,1 ‘-bis-azolylarylmethanes have minima inhibitory concentrations (MIC) higher than that of chlotrimazol, used as positive control. © 1988, The Pharmaceutical Society of Japan. All rights reserved.