Whole body oxygenation using intraperitoneal perfusion of fluorocarbons

Abstract

A preliminary study was allow feasibility of increasing the arterial oxygen tirfjnn, and decreasing tlie arterial carbon dioxide tension, in intact animal by perfusion with the perfluorocarbon-conmining, oxygen-transporting blood substitute, 20% Fluosol-DA. Perfusion was carried out in rabbits using a bubble oxygenator and circulator pump, delivering Fluosol at a rate of 25 ml min-1. Control blood-gas measurements were carried out at various FlOi between 0.5 and (if the animal was not severely hypoxic)0.16. The measurements were repeated during the intraperitoneal perfusion of Fluosol. At all values of Floi, significant increases in Pacn woe seen (P<0.05). Significant decreases of Pacoi (P< 0.05) were seen if the animaU were not hypaxk (Pac>2 > 10 kPa). © 1984 The Macmillan Press Ltd.