Adenosine Deaminase Deficiency: Unanticipated Benefits from the Study of a Rare Immunodeficiency

Abstract

The serendipitous discovery of adenosine deaminase (ADA) deficiency in two patients with cellular immunodeficiency in 1972 by Dr. Eloise Giblett and colleagues ([1][1]) ushered in a new era in the investigation of the molecular mechanisms underlying primary immunodeficiency disorders. This finding