Supercritical Fluid Extraction and Chromatography

Abstract

Utilization of supercritical fluids includes two methods ; extraction (SFE) and chromatography (SFC). The most popular fluid may be carbon dioxide due to its easiness in control in the supercritical state. As a new concept of SFE using carbon dioxide, the programmed extraction elution method (PEEM) that enhances extraction efficiency and selectivity is presented, demonstrating the micro scale SFE preparation of naphthalene and anthracene. Recently, SFC has been developed in various fields as HPLC. The author describes various applications; analysis of a surfactant uising negative temperature gradient elution method, chiral prep-separation of t-stilbene oxide, and separation and detection of SFC-MS.