Study the hypolipidemic effects of Carob (Ceratonia siliqua) and vitamin E in albino rabbits

Abstract

The current study was aimed to determining the effects of carob and vitamin E on liver functions and lipid profile in white rabbits. 20 male rabbits were used in this work, (age 5-6 month) get from local market in Kirkuk city. The rabbits were divided to the following groups (each group was content 5 male): Control group received standard diet, extract group that administrated (orally) with root extract 200mg/kg., extract group that administrated with root extract 400mg/kg., Vit. E group that administrated with vit. E 400mg/kg. Blood was drawn (cardiac puncture) monthly from each group for the duration of the study, which lasted for 5 months. the results showed significant (P<0.05) decreased in the lipid profile parameters (total cholesterol, triglyceride and HDL) especially in the third month after administration of 400mg/kg carob extract group. Also, the results of current study showed significant (P<0.05) decreased in the levels of liver enzymes especially in the third month after administration of 400mg/kg carob extract group. Therefore, it is concluded from the current study that carob play important as hypolipidermic effect and supports the functional aspect liver.