Studies on the Chemistry of Mitomycins

Abstract

The studies on the chemistry of mitomycins are described : i) identification and structural elucidation of mitomycins D, E, F, G, I, J, K, L, M, albomitomycin A, and isomitomycin A from the fermentation broth; ii) derivation of mitomycins structurally close to naturally occurring mitomycins ; iii) mitomycin rearrangement, the interconversion between mitomycin A, albomitomycin A, and isomitomycin A; iv) chemical conversion of isomitomycin A from mitomycin A; v) 3 a-alkoxymitomycins, unexpected by-products in decarbamoylation of mitomycins; vi) the configuration of mitiromycin. © 1990, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.