Krüppel-like factor 6 is a co-activator of nf-kb that mediates p65-dependent transcription of selected downstream genes

Abstract

Background: Transcription factor NF-kB is involved in various biological processes and regulated at multiple levels. Results: KLF6 modulates NF-kB-mediated transcription by promoting binding of p65 to promoters of downstream genes. Conclusion: KLF6 is a co-activator of NF-kB-mediated transcription of selected downstream genes. Significance: Our study reveals a new regulatory mechanism for NF-kB-mediated transcriptional activation in the nucleus. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.