Abnormal accumulation of collagen type i due to the loss of Discoidin domain receptor 2 (Ddr2) promotes testicular interstitial dysfunction

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Abstract

Background Loss of functional allele for discoidin domain receptor 2 (Ddr2) results in impaired Leydig cell response to luteinizing hormone (LH), low testosterone production and arrested spermatogenesis in older male Ddr2<sup>slie/slie</sup> mice. However, the underlying mechanism responsible for this phenotype remains unknown. Herein, we reported for the first time that the deregulated expression of Ddr2 cognate ligand, namely collagen type I (COL1), may account for the disruption of the testicular steroidogenesis in Ddr2<sup>slie/slie</sup> mutant testes.

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Zhu, C. C., Tang, B., Su, J., Zhao, H., Bu, X., Li, Z., … Zhang, Y. Q. (2015). Abnormal accumulation of collagen type i due to the loss of Discoidin domain receptor 2 (Ddr2) promotes testicular interstitial dysfunction. PLoS ONE, 10(7). https://doi.org/10.1371/journal.pone.0131947

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