Journal Article

Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies

Bioorganic and Medicinal Chemistry Letters (2015) 25(18) 3816-3821
DOI: 10.1016/j.bmcl.2015.07.077
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Abstract

Abstract Novel, quinolone-fluoroquinolone conjugates 10a-f, 11a-f, 13a-f and 14a-f with amino acid linkers were synthesized in good yields utilizing benzotriazole chemistry. Antibacterial bioassay showed the synthesized bis-conjugates exhibit anti-bacterial properties comparable with the parent drugs.

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Panda, S. S., Liaqat, S., Girgis, A. S., Samir, A., Hall, C. D., & Katritzky, A. R. (2015). Novel antibacterial active quinolone-fluoroquinolone conjugates and 2D-QSAR studies. Bioorganic and Medicinal Chemistry Letters, 25(18), 3816–3821. https://doi.org/10.1016/j.bmcl.2015.07.077

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