Phytochemistry and pharmacological activities of lepisanthes genus: A review

Abstract

The genus Lepisanthes belonging to the family Sapindaceae consists of trees and shrubs native to tropical Africa, Madagascar, South and Southeast Asia, and northwestern Australia. Herein, we reported a comprehensive review on phytochemical constituents and biological activities of Lepisanthes species from year 1999 to 2021. All the available information and reported studies concerning Lepisanthes plants were summarized from library and digital databases (e.g., Google Scholar, Sci-finder, PubMed, Springer, Elsevier, MDPI, Web of Science, etc.). Approximately 96 chemical constituents have been isolated and reported from Lepisanthes species, such as flavonoids, tannins, saponin triterpenoids, lupane and hopane triterpenes as well as glycosides. Biological activities including anticancer, antimicrobial, antiacetylcholinesterase, antioxidant, antidiabetic, antihyperglycemic and antidiarrheal were demonstrated. This is the first review which highlights the phytochemical and pharmacological studies of different Lepisanthes species. The presented data can be beneficial for any future study.