Effectiveness of Cinnamomum porrectum Roxb. Kosterm Pyroligneous Acid and Its Compounds in Staphylococcus aureus Growth Inhibition

Abstract

The purpose of this study is to assess the antibacterial activity of pyroligneous acid derived from Cinnamomum porrectum (Roxb.) Kosterm stem wood and three types of its constituent chemicals against Staphylococcus aureus. The antibacterial activity of pyroligneous acid produced from C. porrectum was determined using the well diffusion method. The test concentrations varied from 1.56% to 100%, with the lowest to highest concentrations being 1.56%, 3.12%, 6.25%, 12.5%, 25%, 50% vv-1, and 100%. The pure components that make up the pyroligneous acid were also examined at two concentrations: 1.56% and 3.12% vv-1 or mv-1. The negative control was sterile distilled water, while the positive control was clindamycin 0.025% mv-1. Pyroligneous acid's ability to suppress S. aureus ATCC 6538 growth rose as the concentration tested, having MIC and MBC values of 0.39% and 0.78% vv-1, respectively. The principal constituents of C. porrectum pyroligneous acid, 2,6-dimethoxyphenol, 2-hydroxyphenol, and acetic acid, could inhibit S. aureus at a concentration of 1.56% by 12.55; 9.10; 8.33 mm and 16.36; 12.62; 11.48 mm at a concentration of 3.12%, respectively. This pyroligneous acid's potential to suppress the growth of S. aureus has been shown since it comprises acetic acid and phenol derivatives with antibacterial capabilities.