Regulatory implications of translational frameshifting in cellular gene expression

Abstract

The genetic code, once thought to be rigid, hag been found to be quite fiexible, permitting several different reading alternatives. One of these is translatlonal frameshifting, a process programmed in the mRNA sequence and which enables a +1 or ‐1 shift from the reading frame of the initiation codon. So far, the Involvement of translatlonal frameahifting in gene expression has been described mainly in viruses (particularly retroviruses), retrotransposons, and bacterial insertion elements, in this MicroReview., we present a survey of the cellular genes, mostly in Escherichia coil, which have been found to be expressed through a transiational frameshifting process, as well as a discussion of the regulatory implications of this process. Copyright © 1994, Wiley Blackwell. All rights reserved