Solvent- and catalyst-free huisgen cycloaddition to rufinamide in flow with a greener, less expensive dipolarophile

Abstract

Give it a flow: A continuous-flow process for the synthesis of a 1,2,3-triazole precursor of Rufinamide has been developed. The protocol involves a solvent- and catalyst-free operation and utilizes reaction temperatures above the melting point of the target product to prevent microreactor clogging, resulting in a decrease of the operating time from hours to minutes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.