Usefulness of intraoperative continuous infusion of tranexamic acid during emergency surgery for type a acute aortic dissection

Abstract

Purpose: We investigated the influence of intraoperative continuous tranexamic acid (TA) infusion on the amount of blood transfusion required in emergency surgery for type A acute aortic dissection. Methods: The study was based on the data of 55 consecutive patients who underwent surgery for type A acute aortic dissection. The patients were divided into 2 groups for comparison: Group T, consisting of 26 patients who received intraoperative continuous infusion of TA, and Group N, consisting of 29 patients who did not receive TA infusion during the surgery. Results: The mean amounts of blood transfusion required during and after surgery were compared between the 2 groups: they were 10.5 ±8.7 and 16.2 ±10.0 units of mannitoladenine-phosphate-added red cell concentrate, 9.3 ±8.6 and 17.1 ±10.0 units of fresh frozen plasma, and 20.4 ±12.2 and 29.7 ±14.9 units of platelet concentrate, respectively, in Groups T and N. Thus, the amount of each of these blood products required was significantly reduced in Group T. Conclusions: During emergency surgery for type A acute aortic dissection, continuous infusion of TA resulted in a significant reduction in the amount of blood transfusion required.