Inhibitory Activity of Indonesian Soybean in comparison with Soybean Meal on Goblet Cell Count and Micro Vessel Density in Colitis-Associated Mouse Colon Carcinogenesis

Abstract

Colon cancer is a major public health problem throughout the worldwide. Recently, many studies have focused on finding chemoprevention based on the natural compd. The present study was aimed to investigate the inhibitory activity of Indonesian soybean in comparison with soybean meal ext. in colitis-assocd. mouse colon carcinogenesis. Methods: In this study, Swiss Webster mice were induced by azoxymethane 10 mg/kg body wt. followed by administration of 2% dextran sodium sulfate during a week. Soybean, soybean meal ext. at each dose of 75, 150, and 200 mg daily and aspirin 0,39 mg/kg body wt. daily (equiv. to 150 mg for a 70 kg human) administered orally. Histopathol. examn. of the colon tissue (hematoxylin-eosin staining) was done by counting the no. of goblet cells and micro vessel d. in ten randomly selected fields visual. The results: Soybean and soybean meal significantly reduced the count of goblet cell (P<0,05) in colitis-assocd. colon carcinogenesis mice. Soybean ext. is also significantly reduced the no. of micro vessel d. (P<0,001) in colitis-assocd. colon carcinogenesis mice. Otherwise, there were no significant effects of the soybean meal ext. on the no. of micro vessel d. in colitis-assocd. colon carcinogenesis mice. Conclusion: Our results indicate that Indonesian soybean and soybean meal ext. may have inhibitory activity in colitis-assocd. colon carcinogenesis through inhibiting redn. in the no. of goblet cell and micro vessel d. Indonesian soybean may have Inhibitory activity better than soybean meal. [on SciFinder(R)]