Conversion of vindoline into 11-mesyloxytabersonine

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Abstract

Conversion of readily available vindoline to 11-mesyloxytabersonine, a versatile synthetic intermediate for indole alkaloids, has been achieved by a 9-step sequence in 39% overall yield.

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Han-Ya, Y., Inui, T., Yokoshima, S., Tokuyama, H., & Fukuyama, T. (2016). Conversion of vindoline into 11-mesyloxytabersonine. Chemical and Pharmaceutical Bulletin, 64(7), 800–804. https://doi.org/10.1248/cpb.c16-00175

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