Antioxidant Activity of Flavonoid Glycoside Extract of Solanum Betaceum on the Kidney of Wistar Rats

Abstract

Flavonoid glycosides are a type of secondary metabolite that is one of the active chemicals in plants. The antioxidant efficacy of solanum betaceum flavonoid glycosides extract on malondialdehyde levels and superoxide dismutase activity in Wistar rat kidneys with maximum physical activity is the focus of this investigation. The DPPH technique was used to conduct an in vitro activity test. The in vivo test includes four treatment groups: control, stress, ethanol extract, and flavonoid glycoside extract group. Swimming almost one and a half hours every day for five days and being fed and drinking ad libitum is the treatment for stress conditions. Ethanol and flavonoids glycosides extract were given at doses of 50 mg/kg/BW/day respectively. In vitro test result with DPPH technique glycoside flavonoid extract was categorized as a strong antioxidant with an IC50 of 69.89 ppm. The intake of ethanol extract and flavonoid glycoside extract at a dose of 50 mg / Kg BW significantly lower MDA levels (p < 0.05), and can prevent oxidative stress through SOD in Wistar rat kidneys.