Determinants of effective population size for loci with different modes of inheritance

Abstract

Here we report an assessment of the determinants of effective population size (Ne) in species with overlapping generations. Specifically, we used a stochastic demographic model to investigate the influence of different life-history variables on NeI N (where N = population census number) and the influence of sex differences in life-history variables on Ne for loci with different modes of inheritance. We applied an individual-based modeling approach to two datasets: one from a natural population of savannah baboons (Papio cynocephalus) in the Amboseli basin of southern Kenya and one from a human tribal population (the Gainj of Papua New Guinea). Simulation-based estimates of NeIN averaged 0.329 for the Amboseli baboon population (SD = 0.116, 95% Cl = 0.172 - 0.537) and 0.786 for the Gainj (SD = 0.184, 95% Cl = 0.498 - 1.115). Although variance in male fitness had a substantial impact on NeIN in each of the two primate populations, ratios of Ne values for autosomal and sex-linked loci exhibited no significant departures from Poisson-expected values. In each case, similarities in sex-specific Ne values were attributable to the unexpectedly high variance in female fitness. Variance in male fitness resulted primarily from age-dependent variance in reproductive success, whereas variance in female fitness resulted primarily from stochastic variance in survival during the reproductive phase.