Therapeutic potential of cranberry for kidney health and diseases

Abstract

A higher risk of cardiovascular mortality in persons with chronic renal failure (CRF) is linked to inflammation, oxidative stress, cellular aging, and gut dysbiosis, to name a few contributing factors. According to a growing body of evidence, some dietary choices may reduce the severity of certain adverse effects. Specialized databases such as PubMed/Medline, Embase, Google Scholar, and UpToDate were searched to find published studies that focus on the pharmacological effects and mechanisms of cranberries’ bioactive compounds on CRF and human health. Cranberry supplementation has been demonstrated in clinical research to offer health advantages for humans, such as reducing urinary tract infections. Recently, it has been reported that cranberry polyphenols possess anti-inflammatory and antioxidant effects and are also known to have the capacity to affect gut flora. Scientific studies on the beneficial pharmacological effects of cranberries on human health may provide an understanding of traditional cranberry therapy in chronic kidney disease and other chronic conditions. However, translational studies are needed to determine the exact dose that can be administered to humans as well as the validation of nutritional supplements that contain cranberry extract.