The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations. © 2006 Mehra et al.
CITATION STYLE
Mehra, A., Hong, C. I., Shi, M., Loros, J. J., Dunlap, J. C., & Ruoff, P. (2006). Circadian rhythmicity by autocatalysis. PLoS Computational Biology, 2(7), 0816–0823. https://doi.org/10.1371/journal.pcbi.0020096
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