In Vitro Anticestode Activity of Secondary Metabolite of Coleus blumei. Benth Leaves on Hymenolepis microstoma

Abstract

The aim of this study was to determine secondary metabolite of Coleus blumei. Benth leaves which has anticestode activity. Coleus blumei. Benth leaves were extracted which appropriate methods to obtain alkaloid, flavonoid, tannin, and steroid. The anticestode activities of secondary metabolite obtained were evaluated in vitro. Anticestode activity was evaluated with an assay using Hymenopepis microstoma in 10% concentration of metabolite secondary by determination of mortality time. The result of this study showed tannin performed strong anthelmintic activity with no different with praziquatel as commercial anthelmintic product. Aticestode activity flavonoid was similar with tannin but its aticestode activity had lower than commercial anthelmintic. Alkaloid and steroid had lower anticestode activity comparing both tannin and flavonoid. This study revealed that tannin to be a more efficient of biologically active compounds than either flavonoid, alkaloid or steroid.