Clinical profile of 500 cases of polycystic ovary syndrome in a Tertiary Hospital

Abstract

Background: Polycystic ovary syndrome (PCOS) is a common condition affecting 4% to 18% of women. It has been suggested that this condition occurs in as many as 4-10% of women of reproductive age. PCOS is associated with significant reproductive morbidity, including infertility, abnormal uterine bleeding, miscarriage and other complications of pregnancy. Method: This cross-sectional study was carried out in the Department of Obstetrics and Gynaecology of Z.H. Sikder Women's Medical College & Hospital, Dhaka from January, 2013 to December, 2016 over a period of 4 years with the objective to find out various clinical presentations, endocrine status, the menstrual abnormalities and sonographic findings of the patients with PCOS. During the study period a total number of 1600 patients were examined for infertility in the Outpatient and in Inpatient Department. Out of these 1600 infertility patients, 500 cases were found to have polycystic ovary syndrome. Detailed information about the patients were collected in a predesigned data collection sheet. Result: Out of 500 PCOS patients, 360 (72.0%) had primary sub-fertility and 140 (28.0%) had secondary sub-fertility. Age of the patients ranged between 25 and 35 years. Duration of infertility was between 5 to 18 years. Prevalence of menstrual disturbances was found in 78.0 percent of PCOS patients, of which & 90 (18.0%) had amenorrhoea, 250 (50.0%) had oligomenorrhoea, 50 (10.0%) had a heavy menstrual bleeding and 110 (22.0%) had normal menstrual cycle. Among those patients, 210 (42.0%) were obese, 230 (46.0%) had normal BMI and 60 (12.0%) were under weight. Conclusion: The prevalence of PCOS in this study was 31.25% among infertility patients. Among them 72.0% had primary sub-fertility and 28.0% had secondary sub-fertility. Prevalence of menstrual disturbances was found in 78.0% of PCOS patients, of which 18.0% had amenorrhoea, 50.0% had oligomenorrhoea and 10.0% had heavy menstrual bleeding.