Myelodysplastic syndrome (MDS) describes a family of blood disorders driven by the clonal expansion of mutated blood cells that can evolve into secondary acute myeloid leukemia (sAML). Two new studies use single-cell and deep sequencing to elucidate the progression of MDS to AML, revealing discrete clonal architectures and the driving role of signaling mutations.
CITATION STYLE
Romine, K. A., & van Galen, P. (2022, July 1). Rise of the Clones: Myelodysplastic Syndrome to Secondary Acute Myeloid Leukemia. Blood Cancer Discovery. American Association for Cancer Research Inc. https://doi.org/10.1158/2643-3230.BCD-22-0046
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