Syntheses and doxorubicin-inclusion abilities of β-cyclodextrin derivatives with a hydroquinone α-glycoside residue attached at the primary side

Abstract

This paper describes syntheses and doxorubicin-inclusion abilities of β-cyclodextrin (CyD) derivatives with a hydroquinone α-glycoside residue attached at the primary side. The hydroquinone glycoside having an alpha;-D-glucosidic or 2-acetamido-2-deoxy-alpha;-D-glucosidic linkage became a useful component for providing an alpha;-D-glucose- or 2-acetamido-2-deoxy- alpha;-D-glucose-β-CyD conjugate. The surface plasmon resonance analyses of these β-CyD derivatives for the anticancer agent, doxorubicin, indicated that they had excellent inclusion associations on the order of 10 5m-1 for the immobilized doxorubicin. © 2009 Pharmaceutical Society of Japan.