Enhancing the Catalytic Activity of 4-(Dialkylamino)pyridines by Conformational Fixation

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Abstract

Six times more active than DMAP (1), the tricyclic DMAP analogue 2 catalyzes the acetylation of a tertiary alcohol with acetic anhydride. The experimental results can be rationalized by quantum chemical calculations.

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Heinrich, M. R., Klisa, H. S., Mayr, H., Steglich, W., & Zipse, H. (2003). Enhancing the Catalytic Activity of 4-(Dialkylamino)pyridines by Conformational Fixation. Angewandte Chemie - International Edition, 42(39), 4826–4828. https://doi.org/10.1002/anie.200352289

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