Complement factor H binds to human serum apolipoprotein e and mediates complement regulation on high density lipoprotein particles

Abstract

Background: Factor H is the main complement alternative pathway regulator in plasma. Results: Factor H binds to apoE leading to reduced complement activity against HDL particles. Conclusion: Interaction of factor H with HDL particles is involved in complement regulation in plasma. Significance: Complement regulation on HDL particles by factorHcould be involved in disease processes caused by alternative pathway dysregulation.